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November 2020

GENETIC METHOD OF MULTIPOTENT MESENCHYMAL STROMAL CELLS TRANSDIFFERENTIATION INTO HEPATOCYTES

Korotkov A.V.
Candidate of Medical Sciences,
Associate Professor of the Department of Medical Biology and Genetics
Ural State Medical University,
Yekaterinburg, Russia
Sichkar D.A.
Assistant at Department of medical biology and genetics,
Ural State Medical University,
Yekaterinburg, Russia
Shuman E.
Assistant at the Department of medical biology and genetics
Ural State Medical University, Yekaterinburg, Russia
Desyatova M.
Assistant at the Department of medical biology and genetics
Ural State Medical University,
Yekaterinburg, Russia
Kostyukova S.V.
Candidate of Biological Sciences
Associate Professor of the Department of Medical Biology and Genetics,
Ural State Medical University, Yekaterinburg, Russia
Satonkina O.A.
Candidate of Biological Sciences
Associate Professor of the Department of Medical Biology and Genetics,
Ural State Medical University,
Yekaterinburg, Russia
Makeev O.G.
Professor, Doctor of Medical Sciences
Head of the Department of Medical Biology and Genetics of
Ural State Medical University, Yekaterinburg, Russia,
Head of the Laboratory of Gene and Cellular Technologies of
Institute of Medical Cell Technology,
Yekaterinburg, Russia

Abstract
Therapy of liver failure is a common and insufficiently resolved problem. One of the options for its solution
it is a liver transplantation. However, this method has a number of drawbacks, which include a limited number of donors and transplant rejection. The use of autologous hepatocytes would allow significant progress to solve the problem under discussion. The work considers a method that allowed obtaining autologous hepatocytes by transdifferentiation of multipotent mesenchymal stromal cells using genetic engineering methods.


Keywords: multipotent mesenchymal stromal cells transdifferentiation genetic engineering, hepatocytes